Mesothelioma : Remediable Or Irremediable?? 2018 Survival Rates To Overpower This Cancer.
Mesothelioma : Remediable Or Irremediable??
Stages Of Mesothelioma Cancer :
Doctors describe how mesothelioma grows and spreads with 4 stages. Patients diagnosed with stage 1 or stage 2 mesothelioma have the most treatment options. Patients with stage 3 or 4 can improve their quality of life with palliative treatments. Clinical trials are an option for patients at any stage.
The stage of a mesothelioma tumor describes how far it’s spread from where it first appeared in the protective lining of the lungs, abdomen, or heart. The spread of mesothelioma is known as metastasis. The farther mesothelioma has spread, the later doctors stage the disease.
Stage 1: There’s no spread to lymph nodes and the cancer is localized to one side of the body. This is the earliest stage. Stage 1 patients have the most treatment options
Stage 2: Mesothelioma is still localized to one side of the body but there are signs of metastasis to nearby lymph nodes. Aggressive treatment options are still an option.
Stage 3: The first significant signs of metastasis have occurred. Mesothelioma has spread to lymph nodes and surrounding organs. Surgical options become limited.
Stage 4: Mesothelioma has spread to the other side of the body. Treatment options for stage 4 patients primarily involves relieving symptoms.
What is a survival rate?
Statistics on the outlook for a certain type and stage of cancer are often given as survival rates. For example, the 5-year survival rate is the percentage of people who live at least 5 years after being diagnosed with cancer. A 5-year survival rate of 50% means that an estimated 50 out of 100 people who have that cancer are still alive 5 years after being diagnosed. Many of these people live much longer than 5 years after diagnosis.
But keep in mind that survival rates are estimates – your outlook can vary based on a number of factors specific to you.
Mesothelioma Survival Statistics
Statistics tell us that 40% of patients survive the first year after their diagnosis. This is known as the 1-year survival rate for mesothelioma. Scientists often measure mesothelioma life span by 1, 2 and 5-year survival rates.
The 2-year survival rate for mesothelioma is 20%. So a fifth of all patients diagnosed live longer than 2 years. Fewer than 10% of mesothelioma patients live longer than 5 years.
Remember that each individual case of mesothelioma is different. Statistics that apply to others may not apply to you. Your actual life expectancy depends on your treatments, your tumor location and your cell type. These statistics include best and worst case scenarios. They include patients who have received surgery and those who were ineligible.
Summary of mesothelioma survival rates:
- 40% of mesothelioma patients live longer than 1 year.
- 20% of mesothelioma patients live longer than 2 years.
- 10% of mesothelioma patients live live longer than 5 years.
Factors That Affect The Survival Rates To Overpower This Cancer:
Survival rates for mesothelioma cancer vary by the patient’s age, gender, race and several other factors. The location, stage and cell type of the cancer, as well as your overall health, have the strongest influence on your mesothelioma prognosis.
Overall, older mesothelioma patients have a much lower survival rate than younger ones. More than 55 percent of patients diagnosed before the age of 50 live one year. Less than 30 percent of patients 75 or older live the same amount of time.
This difference is largely because younger patients are eligible for more intensive treatments such as surgery. Older individuals may not be candidates for these procedures because of poor overall health or a high risk of complications.
|Age Range||Survival Rate|
|50 – 64||51.2%|
|65 – 74||40.9%|
Rates are similar for long-term survival. Patients diagnosed before age 50 have nearly a 25 percent chance of surviving a decade. That drops sharply — to 5.4 percent — for patients between the ages of 50 and 64.
However, it is rare for someone younger than 50 to be diagnosed with mesothelioma. The average age at diagnosis is 69.
The five-year survival rate for patients diagnosed between ages 65-74 is 6.7 percent. That rate falls to 3.8 percent for those 75 or older.
|Gender||1 Year||2 Years||3 Years||4 Years||5 Years|
Women with mesothelioma have a nearly three-fold better survival rate compared to men. Researchers analyzed mesothelioma cases reported in the National Cancer Institute’s SEER database from 1988 to 2013. They found the overall five-year survival rate was 7 percent for men and 15 percent for women.
Most asbestos exposure occurs in the workplace. Industrial jobs traditionally held by men presented the highest risk. That helps explain why men account for the majority of all mesothelioma cases.
When asbestos use was far more pervasive decades ago, the few women who did develop a related illness were usually exposed because they lived near mines or factories that processed the mineral. Women also found themselves exposed by spouses, family members or friends who worked around asbestos and brought home the tiny fibers on their clothes.
Women with mesothelioma appear to survive longer than men regardless of age, cancer stage, race or type of treatment. For every age group studied in the SEER program, women fared significantly better than men.
There is currently no conclusive answer as to why. Some researchers believe the improved survival could be explained by hormonal differences between sexes.
Women are also more likely to be diagnosed with peritoneal mesothelioma. This type carries a better prognosis compared to the more common pleural type.
Mesothelioma is almost exclusive to white individuals, who make up 95 percent of patients.
This vast difference may be in large part because black and Hispanic individuals are less likely to be diagnosed with any type of cancer, mesothelioma included. Data from SEER shows blacks and Hispanics account for only 8 percent of all cancer diagnoses.
|Race||1 Year||2 Years||3 Years||4 Years||5 Years|
Race does not appear to impact mesothelioma survival rate much initially. It becomes a more telling factor as time passes. From three years on, the survival rate of white patients is slightly worse than black patients.
Five-year survival among whites is 7.8 percent, compared with 12 percent for blacks. After 10 years, only 4.4 percent of white patients survive, while 8.2 percent of blacks are alive a decade after diagnosis.
SEER data used to calculate these survival rates includes Hispanics among patients who identify as both black and white. Because mesothelioma is rarer among other races, reliable survival statistics are not available.
A 2015 study analyzed 13,734 pleural mesothelioma cases in the SEER database. It found that black patients lived longer than white patients despite being less likely to undergo aggressive surgery. Only 18 percent of black patients in the study had surgery, compared to 24 percent of white patients.
Typically, mesothelioma patients who have surgery survive longer than those who do not.
Site of Mesothelioma
There are four types of mesothelioma, and the site where the cancer originates can greatly affect patient survival.
Survival is significantly better for peritoneal mesothelioma patients. This, however, has not always been the case.
The emergence of an advanced peritoneal mesothelioma therapy called hyperthermic intraperitoneal chemotherapy (HIPEC) improved survival rates. It combines cytoreductive surgery and heated chemotherapy. Not everyone qualifies for this aggressive procedure. But about half who do live at least five years.
This compares to a median survival of less than 12 months for patients with pleural mesothelioma. In select studies, heated chemotherapy has boosted peritoneal mesothelioma survival to between 40 and 92 months.
According to a 2015 meta-study analyzing 20 years of data from 1992 to 2012, the five-year survival rate for peritoneal mesothelioma patients is more than five-times higher than the rate for pleural patients.
The remaining two types — pericardial and testicular mesothelioma — when combined, account for less than 2 percent of all mesothelioma cases. Median survival for testicular mesothelioma, the rarest type, is 24 months.
Other Factors That Affect The Survival Rates :
- Cancer stage and location. People in earlier mesothelioma stages live longer than people in later stages. And those with Peritoneal Mesothelioma have better survival rates than Pleural Mesothelioma. There are different treatments based on the location and stage of your tumors. Different treatments have a different impact on your life span.
- Cell type. Patients with epithelioid cell types live longer than those with other cell types. Patients with sarcomatoid or mixed cell types have the shortest life spans.
- Overall health. If you are healthy at the time of diagnosis, your lifespan tends to be longer than average. You tend to tolerate the various procedures and chemotherapy better if you are healthier. You’re also more likely to be eligible for surgery.
- Blood factors. If you have a high platelet count and a high white blood cell count, you may have a shorter lifespan.
- Experimental treatments. If you join a clinical trial, there is a chance that the treatment will be better than existing treatments. Clinical trials have given some patients alternatives when traditional treatment wasn’t working. Some treatments showing promise are immunotherapy and photodynamic therapy.
Treatment for mesothelioma is getting better and better, patients are living longer. Clinical trials are also helping extend people’s lives.